ForsLean® – One of Lean & Fab’s U.S.-Patented Ingredients

Introduction

ForsLean® is an extract prepared from Coleus forskohlii roots and standardized for a minimum of 10% forskolin. It is a registered trademark and patented product of Sabinsa Corporation.

Careful cultivation is essential for optimizing the quality of root material for forskolin content. Critical factors that affect the growth and yield of C. forskohlii include climate and soil requirements. C. forskohlii is a species native to subtropical and warm, temperate habitats, and it grows well in loamy or sandy-loam soil which has a pH of 6.4 to 7.9. Approximately, 1-500 g of root material can be obtained from a single plant, and the forskolin content of the roots varies from 0.07-0.58% on a dried basis

 

Forskolin has mutifaceted pharmacological effects that have been linked to its role as an activator of adenylate cyclase.3 Adenylate cyclase is the enzyme involved in the production of cyclic adenosine monophosphate (cAMP), a significant biochemical agent involved in essential metabolic processes. Cyclic AMP is called the “second messenger” because it facilitates the action of “primary messengers”, various hormonal and bioactive substances in the body.
Based on its pharmacological actions, forskolin appears to be well indicated in conditions, such as eczema (atopic dermatitis), asthma,
psoriasis, cardiovascular disorders, and hypertension, where decreased intracellular cAMP levels is believed to be a major factor in the development of the disease process.

In promoting weight management, forskolin induces a chain of biochemical events that trigger the metabolic processes and diet-induced thermogenesis8, thereby providing the means to maintain a healthy body composition and lean body mass levels.

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